Đăng xuất
Pharmacology: Pharmacodynamics: Resistance to many antibiotics is caused by bacterial enzyme which destroy the antibiotic before it can act on the pathogen. The clavulanate in AUGMENTIN anticipates this defence mechanism by blocking the β-lactamase enzymes, thus, rendering the organisms susceptible to amoxicillin's rapid bactericidal effect at concentrations readily attainable in the body. Clavulanate by itself has little antibacterial activity; however, in association with amoxicillin as AUGMENTIN, it produces an antibiotic agent of broad spectrum with wide application in hospital and general practice.
AUGMENTIN is bactericidal to a wide range of organisms including: Gram-Positive: Aerobes: Enterococcus faecalis, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus viridans, *Staphylococcus aureus, *coagulase negative staphylococci (including Staphylococcus epidermidis), Corynebacterium spp, Bacillus anthracis, Listeria monocytogenes.
Anaerobes: Clostridium spp, Peptococcus spp, Peptostreptococcus.
Gram-Negative: Aerobes: *Haemophilus influenzae,*Escherichia coli, *Proteus mirabilis, *Proteus vulgaris, *Klebsiella spp, *Moraxella catarrhalis, *Salmonella spp, *Shigella spp, Bordetella pertussis, Brucella spp, *Neisseria gonorrhoeae, Neisseria meningitidis, Vibrio cholerae, Pasteurella multocida.
Anaerobes: *Bacteroides spp, including fragilis.
*including β-lactamase producing strains resistant to ampicillin and amoxicillin.
